منابع مشابه
Genetic and Epigenetic landscape of Germline Stem Cells
Elucidating the critical epigenetics events involved in differentiation and reprogramming of cells to primordial germ cells (PGCs) is among the interesting issues in stem cell research. Here, I will talk about critical transcription factors and global hypomethylation in development of germ cells. Evidence strongly suggests that the earliest PGCs emerging in the E7.25 mouse embryo epiblast have...
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The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...
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Mesenchymal stem cells can be obtained from deferent tissues like adipose tissue, umbilical cord, placenta, skin, bone marrow, etc. These cells have regulatory effects on all types of immune cells such as dendritic cell, natural killers and lymphocytes. Mesenchymal stem cells induce inhibitory phenotypes of Antigen Presenting Cells (APCs) following their activity. They also change T cells pheno...
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Introduction: Alzheimer disease (AD), known to be a leading cause of dementia that causes heavy social and financial burdens worldwide, characterized by progressive loss of neurons and synaptic connectivity after depositions of amyloid-β (Aβ) protein.AD manifests as an impaired ability to comprehend or use words, poor coordination and gait, and impaired executive functions in the realms of plan...
متن کاملgenetic and epigenetic landscape of germline stem cells
elucidating the critical epigenetics events involved in differentiation and reprogramming of cells to primordial germ cells (pgcs) is among the interesting issues in stem cell research. here, i will talk about critical transcription factors and global hypomethylation in development of germ cells. evidence strongly suggests that the earliest pgcs emerging in the e7.25 mouse embryo epiblast have ...
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ژورنال
عنوان ژورنال: Cell Proliferation
سال: 2007
ISSN: 0960-7722
DOI: 10.1111/j.1365-2184.2008.00487.x